Virtual Colonoscopy recommended as a primary
screening test before therapeutic Optical Colonoscopy
Highly anticipated trial results published in the October 4, 2007 edition of the New England Journal of Medicine [attached] marked the end of a long road to validation for virtual colonoscopy (VC or CT Colonography [CTC]). Preliminary results of the National CT Colonography Trial (ACRIN 6664), a study funded by the National Institutes of Health (NIH) and performed on 2,531 participants in 15 U.S. centers, yielded an impressive per-patient sensitivity of 90% for adenomatous coldiameter, a sensitivity on par with that of optical colonoscopy.
The study was performed with a low-dose CT technique yielding a total dose of about 5mSv per exam, an amount the Health Physics Society considers a risk that is either nonexistent or too small to be measured.
Tens of millions of people eligible for colon cancer screening every year shy away from stool tests and the invasive colonoscopy exam. Colon cancer is the second most common cancer killer in the U.S., affecting one in 18 individuals in the United States: 145,290 new cases in 2007, and an estimated 73,470 deaths. Yet only one-third to one-half of the 70 million people eligible to screen in the U.S. ever get tested.
The virtual imaging study had 90% sensitivity and 86% specificity for adenomas 1 cm or larger. Performance characteristics remained high in smaller sized polyps, with 84% sensitivity in lesions 7 mm or bigger. Specificity remained high (86% to 89%) across all relevant lesion sizes.
Sensitivity and specificity aside, the results also indicate most patients undergoing VC would not need subsequent colonoscopy, sparing them cost, risk and inconvenience of a second test. Only 8.3% of trial participants would have proceeded to same-day optical colonoscopy for removal of polyps 6 mm or larger, a referral rate low enough to suggest that VC will not be too expensive an alternative for routine use in colorectal cancer screening.
The study concludes that: 1.) primary VC and OC screening strategies resulted in similar detection rates for advanced neoplasia, 2.) the numbers of polypectomies and complications were considerably smaller in the VC group, and 3.) the findings support the use of VC as a primary screening test before therapeutic OC.
Proposed guidelines for appropriateness of either CTC or OC are as follows:
Virtual Colonoscopy
- Routine surveillance after age 50 or earlier if family history
- Patients taking anticoagulants
- Difficult OC due to spastic bowels
- Suspect extra colonic disease.
- Failed OC
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Optical Colonoscopy
- Prior polypectomy less than 5 years
- Suspect inflammatory bowel disease
- Rectal bleeding
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EBT Heart & Body Imaging has been performing Virtual Colonoscopy in Michigan for since 200X, and our medical director, Dr. Marc Kahn has been a leading national proponent for its use as a viable alternative to enhance patient compliance for this important screening.
For more information, please call 248-358-3225.
Read the full New England Journal of Medicine article